The regression analysis showed that ESS was significantly associated with the disease severity of COVID-19 (HR = 2.515, 95% CI: 1.050-6.026, P = 0.039). The levels of erythrocyte sedimentation rate and C-reactive protein, and the positive rate of procalcitonin were significantly higher, whereas the lymphocyte count was apparently lower in ESS patients than in non-ESS patients. ESS patients had higher proportions of fever, shortness of breath, hypertension, diabetes, and severe events than those of non-ESS patients. RESULTS: Forty-one (27.52%) cases of COVID-19 patients diagnosed with ESS. Subsequently, a receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performances of FT3 and C-reactive protein (CRP) in the disease severity. Kaplan-Meier curve and cox regression model were utilized to determine the correlation between ESS and the endpoints. METHODS: Clinical and laboratory data of COVID-19 patients with or without ESS in Changsha, China, were collected and analyzed on admission.
In this study, the thyroid function of COVID-19 patients was assessed and factors associated with outcomes were analyzed to determine the potential predictive value of ESS. Euthyroid sick syndrome (ESS) is usually associated with the disease severity and deterioration prognosis in critical illness. However, it is not clear whether the thyroid gland is impaired in COVID-19 patients. BACKGROUND: Coronavirus disease 2019 (COVID-19) has been shown to affect almost every organ throughout the body. The hormone responses in euthyroid sick syndrome represent part of an adaptive response, which lowers tissue energy requirement in systemic illness.
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